Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma

Background: Boron neutron capture therapy (BNCT) is a binary modality based on the nuclear reaction 10B (n, α) lithium-7 (7Li) that has been used to treat variety of tumors, among these, cutaneous melanoma (CM). In previous boron biodistribution studies in agreement with personalized oncology, we have demonstrated boronophenylalanine (BPA) uptake can be correlated tumoral temperature and viability. The main aim these was evaluate relationship between response complete BNCT.